USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P48426 USC-OGP 2-DE database:  P48426 P48426 General information about the entry View entry in simple text format Entry name PI42A_HUMAN Primary accession number P48426 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; EC=2.7.1.149; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; AltName: Full=Diphosphoinositide kinase 2-alpha; AltName: Full=PIP5KIII; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II alpha; Short=PI(5)P 4-kinase type II alpha; Short=PIP4KII-alpha; AltName: Full=PtdIns(4)P-5-kinase B isoform; AltName: Full=PtdIns(4)P-5-kinase C isoform; AltName: Full=PtdIns(5)P-4-kinase isoform 2-alpha;. Gene name Name=PIP4K2A Synonyms=PIP5K2, PIP5K2A Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0915: pI=6.44; Mw=49481 Cross-references UniProtKB/Swiss-Prot P48426; PI42A_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PI42A_HUMAN Primary accession number P48426 Secondary accession number(s) B0YJ66 B4DGX2 D3DRV1 P53807 Q5VUX3 Sequence was last modified on  August 14, 2001 (version 2) Annotations were last modified on  March 15, 2017 (version 149) Name and origin of the protein Description RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; EC=2.7.1.149; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; AltName: Full=Diphosphoinositide kinase 2-alpha; AltName: Full=PIP5KIII; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II alpha; Short=PI(5)P 4-kinase type II alpha; Short=PIP4KII-alpha; AltName: Full=PtdIns(4)P-5-kinase B isoform; AltName: Full=PtdIns(4)P-5-kinase C isoform; AltName: Full=PtdIns(5)P-4-kinase isoform 2-alpha; Gene name Name=PIP4K2A Synonyms=PIP5K2, PIP5K2A Encoded on Name=PIP4K2A; Synonyms=PIP5K2, PIP5K2A Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U14957; AAA64835.2; -; mRNA EMBL S78798; AAB35041.1; -; mRNA EMBL AL513128; CAH72211.1; -; Genomic_DNA EMBL AL157707; CAH72211.1; JOINED; Genomic_DNA EMBL AL390318; CAH72211.1; JOINED; Genomic_DNA EMBL AK294817; BAG57933.1; -; mRNA EMBL EF445009; ACA06044.1; -; Genomic_DNA EMBL EF445009; ACA06045.1; -; Genomic_DNA EMBL AL157707; CAI39585.1; -; Genomic_DNA EMBL AL390318; CAI39585.1; JOINED; Genomic_DNA EMBL AL513128; CAI39585.1; JOINED; Genomic_DNA EMBL AL390318; CAH70526.1; -; Genomic_DNA EMBL AL157707; CAH70526.1; JOINED; Genomic_DNA EMBL AL513128; CAH70526.1; JOINED; Genomic_DNA EMBL CH471072; EAW86140.1; -; Genomic_DNA EMBL CH471072; EAW86141.1; -; Genomic_DNA EMBL BC018034; AAH18034.1; -; mRNA CCDS CCDS7141.1; -. [P48426-1]; . CCDS CCDS81443.1; -. [P48426-2]; . PIR A55967; A55967; . PIR S57217; S57217; . RefSeq NP_001316991.1; NM_001330062.1. [P48426-2]; . RefSeq NP_005019.2; NM_005028.4. [P48426-1]; . RefSeq XP_016871819.1; XM_017016330.1. [P48426-2]; . RefSeq XP_016871820.1; XM_017016331.1. [P48426-2]; . UniGene Hs.57079; -; . PDB 2YBX; X-ray; 2.56 A; A/B=35-405 PDBsum 2YBX; -; . ProteinModelPortal P48426; -; . SMR P48426; -; . BioGrid 111322; 102; . IntAct P48426; 6; . MINT MINT-1507380; -; . STRING 9606.ENSP00000365757; -; . ChEMBL CHEMBL1795194; -; . SwissLipids SLP:000000855; -; . iPTMnet P48426; -; . PhosphoSitePlus P48426; -; . BioMuta PIP4K2A; -; . DMDM 18266879; -; . OGP P48426; -; . EPD P48426; -; . MaxQB P48426; -; . PaxDb P48426; -; . PeptideAtlas P48426; -; . PRIDE P48426; -; . DNASU 5305; -; . Ensembl ENST00000376573; ENSP00000365757; ENSG00000150867. [P48426-1]; . Ensembl ENST00000545335; ENSP00000442098; ENSG00000150867. [P48426-2]; . GeneID 5305; -; . KEGG hsa:5305; -; . UCSC uc001irl.5; human. [P48426-1]; . CTD 5305; -; . DisGeNET 5305; -; . GeneCards PIP4K2A; -; . HGNC HGNC:8997; PIP4K2A; . HPA HPA065440; -; . HPA HPA068771; -; . MalaCards PIP4K2A; -; . MIM 603140; gene; . neXtProt NX_P48426; -; . OpenTargets ENSG00000150867; -; . Orphanet 99860; Precursor B-cell acute lymphoblastic leukemia; . PharmGKB PA162399615; -; . eggNOG KOG0229; Eukaryota; . eggNOG COG5253; LUCA; . GeneTree ENSGT00760000119184; -; . HOGENOM HOG000007832; -; . HOVERGEN HBG000072; -; . InParanoid P48426; -; . KO K00920; -; . OMA IVECHGV; -; . OrthoDB EOG091G0857; -; . PhylomeDB P48426; -; . TreeFam TF354315; -; . BioCyc MetaCyc:HS07693-MONOMER; -; . Reactome R-HSA-1660499; Synthesis of PIPs at the plasma membrane; . Reactome R-HSA-6811555; PI5P Regulates TP53 Acetylation; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-8847453; Synthesis of PIPs in the nucleus; . SIGNOR P48426; -; . ChiTaRS PIP4K2A; human; . GeneWiki PIP4K2A; -; . GenomeRNAi 5305; -; . PRO PR:P48426; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000150867; -; . CleanEx HS_PIP4K2A; -; . ExpressionAtlas P48426; baseline and differential; . Genevisible P48426; HS; . GO GO:0005776; C:autophagosome; IMP:ParkinsonsUK-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0052811; F:1-phosphatidylinositol-3-phosphate 4-kinase activity; TAS:Reactome; . GO GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; NAS:UniProtKB; . GO GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; EXP:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0035855; P:megakaryocyte development; IEA:Ensembl; . GO GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome; . GO GO:0006644; P:phospholipid metabolic process; TAS:Reactome; . GO GO:2000786; P:positive regulation of autophagosome assembly; IMP:ParkinsonsUK-UCL; . GO GO:0010506; P:regulation of autophagy; IMP:ParkinsonsUK-UCL; . GO GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; TAS:Reactome; . Gene3D 3.30.800.10; -; 1; . Gene3D 3.30.810.10; -; 1; . InterPro IPR023610; PInositol-4-P-5-kinase; . InterPro IPR027483; PInositol-4-P-5-kinase_C; . InterPro IPR002498; PInositol-4-P-5-kinase_core; . InterPro IPR027484; PInositol-4-P-5-kinase_N; . PANTHER PTHR23086; PTHR23086; 1; . Pfam PF01504; PIP5K; 1; . SMART SM00330; PIPKc; 1; . PROSITE PS51455; PIPK; 1; .

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